Evidens och insikter

Våra kliniska sidor bygger på riktlinjer, systematiska översikter och publicerade studier. Här finns alla källor samlade i en sökbar referensdatabas.

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Källor

Referensdatabas

Alla källor som används på våra kliniska sidor. Filtrera på sida eller sök på författare, titel och år.

  1. Elad et al., 2020 HTM-REF-001

    Elad S, Cheng KKF, Lalla RV, Yarom N, Hong C, Logan RM, et al. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 2020;126(19):4423-4431.

  2. NICE, 2018 HTM-REF-002

    National Institute for Health and Care Excellence. Low-level laser therapy for preventing or treating oral mucositis caused by radiotherapy or chemotherapy. NICE HealthTech Guidance HTG472. Published 23 May 2018, migrated from IPG615 January 2026 without change to the recommendations. NICE HTG472.

  3. Patel et al., 2021 HTM-REF-003

    Patel P, Robinson PD, Baggott C, Gibson P, Ljungman G, Massey N, et al. Clinical practice guideline for the prevention of oral and oropharyngeal mucositis in pediatric cancer and hematopoietic stem cell transplant patients: 2021 update. Eur J Cancer. 2021;154:92-101.

  4. ARIA Guide, 2023 HTM-REF-004

    ARIA Guide. Supportive Care: Mucositis Clinical Practice Recommendations. Version 1.4.1, September 2023. St. Jude Children's Research Hospital and ARIA Guide global partners. Copyright 2025. ARIA/St. Jude Mucositis Clinical Practice Recommendations.

  5. de Freitas och Hamblin, 2016 HTM-REF-005

    de Freitas LF, Hamblin MR. Proposed mechanisms of photobiomodulation or low-level light therapy. IEEE J Sel Top Quantum Electron. 2016;22(3):7000417.

  6. Hamblin, 2018 HTM-REF-006

    Hamblin MR. Mechanisms and mitochondrial redox signaling in photobiomodulation. Photochem Photobiol. 2018;94(2):199-212.

  7. Kauark-Fontes et al., 2023 HTM-REF-007

    Kauark-Fontes E, Migliorati CA, Epstein JB, Bensadoun RJ, Gueiros LAM, Carroll J, et al. Twenty-year analysis of photobiomodulation clinical studies for oral mucositis: a scoping review. Oral Surg Oral Med Oral Pathol Oral Radiol. 2023;135(5):626-641.

  8. Nascimento et al., 2023 HTM-REF-008

    Nascimento MV, Costa FWG, Oliveira Filho OV, Silva PGB, Pontes KMF. Management of cancer therapy-induced oral mucositis using photobiomodulation therapy: an overview of systematic reviews. Photobiomodul Photomed Laser Surg. 2023;41(10):513-538.

  9. Cruz et al., 2023 HTM-REF-009

    Cruz AR, Minicucci EM, Betini M, Almeida-Lopes L, Tieghi Neto V, Cataneo AJM. Efficacy of photobiomodulation in the treatment of oral mucositis in patients undergoing antineoplastic therapy: systematic review and meta-analysis. Support Care Cancer. 2023;31(12):645.

  10. Guimaraes et al., 2021 HTM-REF-010

    Guimaraes DM, Ota TMN, Da Silva DAC, Almeida FLS, Schalch TD, Deana AM, et al. Low-level laser or LED photobiomodulation on oral mucositis in pediatric patients under high doses of methotrexate: prospective, randomized, controlled trial. Support Care Cancer. 2021;29(11):6441-6447.

  11. Arbetsmiljöverket, 2023 HTM-REF-011

    Arbetsmiljöverket. AFS 2023:10 Risker i arbetsmiljön. Bestämmelser om artificiell optisk strålning och användning av laserskyddsglasögon vid laserklass 3B och 4. Arbetsmiljöverket AFS 2023:10.

  12. Strålsäkerhetsmyndigheten, 2025 HTM-REF-012

    Strålsäkerhetsmyndigheten. Laserklasser samt Hälsorisker med laser. Senast uppdaterade 3 juli 2025. Strålsäkerhetsmyndigheten - laserklasser.

  13. Zadik et al., 2021 HTM-REF-013

    Zadik Y, Arany PR, Fregnani ER, et al. Supportive care of cancer patients with a self-applied photobiomodulation device: a case series. Support Care Cancer. 2021.

  14. Salman et al., 2025 HTM-REF-014

    Salman S, Abdalla-Aslan R, Awawdi A, Tarabeih R, Billan S. From clinic to couch: a pilot study of home-use photobiomodulation for radiation-induced oral mucositis and dermatitis. Support Care Cancer. 2025;33(12):1023.

  15. THOR Photomedicine, 2026 HTM-REF-015

    THOR Photomedicine. LX2.3 Laser and LED Therapy System and interchangeable treatment probes: THOR LED Lollipop S2197, Large LED Cluster S2140, laser probes and clusters. Product specifications. Accessed September 2026. THOR product specifications.

  16. Bensadoun et al., 2020 HTM-REF-016

    Bensadoun RJ, Epstein JB, Nair RG, Barasch A, Raber-Durlacher JE, Migliorati C, et al. Safety and efficacy of photobiomodulation therapy in oncology: a systematic review. Cancer Med. 2020;9(22):8279-8300.

  17. RCC Mun- och tandhälsa, u.å. HTM-REF-017

    Regionala cancercentrum i samverkan. Nationellt vårdprogram Cancerrehabilitering. Avsnitt 9, Fysiska insatsområden - mun- och tandhälsa. Regionala cancercentrum i samverkan. Aktuell webbversion.

  18. Hong et al., 2019 HTM-REF-018

    Hong CHL, Gueiros LA, Fulton JS, et al. Systematic review of basic oral care for the management of oral mucositis in cancer patients and clinical practice guidelines. Support Care Cancer. 2019;27:3949-3967.

  19. Elad et al., 2015 HTM-REF-019

    Elad S, Raber-Durlacher JE, Brennan MT, et al. Basic oral care for hematology-oncology patients and hematopoietic stem cell transplantation recipients: a position paper from the joint task force of MASCC/ISOO and EBMT. Support Care Cancer. 2015;23:223-236.

  20. Zadik et al., 2019 HTM-REF-020

    Zadik Y, Arany PR, Fregnani ER, et al. Systematic review of photobiomodulation for the management of oral mucositis in cancer patients and clinical practice guidelines. Support Care Cancer. 2019;27:3969-3983.

  21. Grzech-Leśniak et al., 2025 HTM-REF-021

    Grzech-Leśniak K, Fiegler-Rudol J, Grzech-Leśniak Z, et al. Laser therapy for the management of oral mucositis: an umbrella review - official recommendations of the Polish Society for Laser Dentistry. Dent Med Probl. 2025;62(6):1157-1175.

  22. Eichhorn et al., 2025 HTM-REF-022

    Eichhorn S, Rudin L, Ramasamy C, et al. Elevated likelihood of infectious complications related to oral mucositis after hematopoietic stem cell transplantation: a systematic review and meta-analysis of outcomes and risk factors. Cancers (Basel). 2025;17(16):2657.

  23. RCC Perifer neuropati, u.å. HTM-REF-023

    Regionala cancercentrum i samverkan. Cytostatikaorsakad perifer neuropati. RCC Kunskapsbanken. Nationellt stöddokument.

  24. RCC Cancerrehabilitering, u.å. HTM-REF-024

    Regionala cancercentrum i samverkan. Nationellt vårdprogram Cancerrehabilitering - symtom och biverkningar som kan påverka funktionsförmåga.

  25. Jordan et al., 2020 HTM-REF-025

    Jordan B, Margulies A, Cardoso F, et al. Systemic anticancer therapy-induced peripheral and central neurotoxicity: ESMO-EONS-EANO Clinical Practice Guidelines for diagnosis, prevention, treatment and follow-up. Ann Oncol. 2020;31(10):1306-1319.

  26. Seidman et al., 2008 HTM-REF-026

    Seidman AD, Berry D, Cirrincione C, et al. Randomized phase III trial of weekly compared with every-3-weeks paclitaxel for metastatic breast cancer: CALGB 9840. J Clin Oncol. 2008;26(10):1642-1649.

  27. Michel et al., 2025 HTM-REF-027

    Michel LL, Schwarz D, Romar P, et al. Efficacy of Hand Cooling and Compression in Preventing Taxane-Induced Neuropathy: The POLAR Randomized Clinical Trial. JAMA Oncol. 2025;11(4):408-415.

  28. Johnson et al., 2024 HTM-REF-028

    Johnson K, Stoffel B, Schwitter M, et al. Prevention of taxane chemotherapy-induced nail changes and peripheral neuropathy by application of extremity cooling: a prospective single-centre study with intrapatient comparison. Support Care Cancer. 2024;32:554.

  29. Oneda et al., 2020 HTM-REF-029

    Oneda E, et al. Innovative approach for the prevention of chemotherapy-induced peripheral neuropathy in cancer patients: a pilot study with the Hilotherm device. Integr Cancer Ther. 2020;19:1534735420943287.

  30. Tai et al., 2024 HTM-REF-031

    Tai HY, Lin LY, Huang TW, Gautama MSN. Efficacy of cryotherapy in the prevention of chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis. Support Care Cancer. 2024;32:482.

  31. Engvall et al., 2021 HTM-REF-032

    Engvall K, Gréen H, Fredrikson M, et al. Persistent neuropathy among early-stage breast cancer survivors in a population-based cohort. Br J Cancer. 2021;125:445-457.

  32. Engvall et al., 2022 HTM-REF-033

    Engvall K, et al. Impact of persistent peripheral neuropathy on health-related quality of life among early-stage breast cancer survivors: a population-based cross-sectional study. Breast Cancer Res Treat. 2022;195:379-391.

  33. Brunner et al., 2024 HTM-REF-034

    Brunner C, Emmelheinz M, Egle D, et al. CROPSI study: Efficacy and safety of cryotherapy and cryocompression in preventing chemotherapy-induced peripheral neuropathy in patients with breast and gynecological cancer. The Breast. 2024;76:103763.

  34. Loprinzi et al., 2020 HTM-REF-035

    Loprinzi CL, Lacchetti C, Bleeker J, et al. Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: ASCO Guideline Update. J Clin Oncol. 2020;38(28):3325-3348.

  35. Tsuyuki et al., 2016 HTM-REF-036

    Tsuyuki S, Senda N, Kanng Y, et al. Evaluation of compression therapy using surgical gloves on nab-paclitaxel-induced peripheral neuropathy: a phase II multicenter study. Breast Cancer Res Treat. 2016;160:61-67.

  36. Jia et al., 2021 HTM-REF-037

    Jia J, Guo Y, Sundar R, Bandla A, Hao Z. Cryotherapy for Prevention of Taxane-Induced Peripheral Neuropathy: A Meta-Analysis. Front Oncol. 2021;11:781812.

  37. Coolbrandt et al., 2022 HTM-REF-038

    Coolbrandt A, Vancoille K, Dejaeger E, et al. Preventing taxane-related peripheral neuropathy, pain and nail toxicity: a prospective self-controlled trial comparing hilotherapy with frozen gloves in early breast cancer. Breast Cancer Res Treat. 2022;192:293-301.

  38. Coolbrandt et al., 2023 HTM-REF-039

    Coolbrandt A, Tobback H, Govaerts R, et al. A randomized controlled trial of hand/foot-cooling by hilotherapy to prevent oxaliplatin-related peripheral neuropathy in patients with malignancies of the digestive system. ESMO Open. 2023;8(2):101205.

  39. RCC, 2026 HTM-REF-040

    Regionala cancercentrum i samverkan (RCC). Nationellt vårdprogram cancerrehabilitering. Avsnitt: Symtom och biverkningar som kan påverka funktionsförmåga – håravfall. RCC Kunskapsbanken. Aktuell webbversion 2026.

  40. RCC Håravfall vid bröstcancer, u.å. HTM-REF-041

    Regionala cancercentrum i samverkan (RCC). Min vårdplan. Patientinformation om håravfall vid cytostatikabehandling. RCC Kunskapsbanken.

  41. Lacouture et al., 2021 HTM-REF-042

    Lacouture ME, Sibaud V, Gerber PA, van den Hurk C, Fernández-Peñas P, Santini D, et al. Prevention and management of dermatological toxicities related to anticancer agents: ESMO Clinical Practice Guidelines. Ann Oncol. 2021;32(2):157-170.

  42. Lambert et al., 2024 HTM-REF-043

    Lambert KA, Albright BB, Anastasio MK, Kaplan SJ, McNally L. Scalp hypothermia to reduce chemotherapy-induced alopecia: A systematic review and meta-analysis. Gynecol Oncol. 2024;188:71-80.

  43. Freites-Martinez et al., 2025 HTM-REF-044

    Freites-Martinez A, Apalla Z, Shapiro J, et al. Expert consensus for prevention, diagnosis and management of persistent chemotherapy-induced alopecia. J Eur Acad Dermatol Venereol. 2025;39(12):2039-2046.

  44. Nangia et al., 2017 HTM-REF-045

    Nangia J, Wang T, Osborne C, et al. Effect of a Scalp Cooling Device on Alopecia in Women Undergoing Chemotherapy for Breast Cancer: The SCALP Randomized Clinical Trial. JAMA. 2017;317(6):596-605.

  45. Kaufman et al., 2025 HTM-REF-046

    Kaufman L, Valentic L, Malley L, Icksarus C, Rose L, Dulmage B. Scalp cooling therapy in chemotherapy-induced alopecia: addressing variability in cooling duration and efficacy. Support Care Cancer. 2025;33(11):1005.

  46. 1177 Vårdguiden, u.å. HTM-REF-047

    1177 Vårdguiden. Behandling med cytostatika vid cancer. Avsnitt: Använd en kylmössa. Nationell patientinformation.

  47. Kearney et al., 2025 HTM-REF-048

    Kearney CA, Brinks AL, Needle CD, Adhikari S, Marks DK, Shapiro J, et al. Adverse effects of scalp cooling for the reduction of chemotherapy-induced alopecia: A systematic review and meta-analysis. Breast Cancer Res Treat. 2025;215(1):11.

  48. Hilotherm, 2025 HTM-REF-049

    Hilotherm GmbH. Instructions for Use HILOTHERM HT02 ChemoCare CIA. HT02 CIA-GAN-EN 2025-08-26 cs. Version 26 August 2025. Kompletterad med Hilotherm GmbH, Controlled Scalp Cooling – HILOTHERAPY ChemoCare CIA, produktinformation.

  49. RCC Bäckencancerrehabilitering, u.å. HTM-REF-051

    Regionala cancercentrum i samverkan. Nationellt vårdprogram bäckencancerrehabilitering.

  50. RCC Lymfödem, u.å. HTM-REF-052

    Regionala cancercentrum i samverkan. Bäckencancerrehabilitering - lymfödem.

  51. RCC Livmoderkroppscancer, u.å. HTM-REF-053

    Regionala cancercentrum i samverkan. Nationellt vårdprogram livmoderkroppscancer - omvårdnad och rehabilitering.

  52. RCC Min vårdplan huvud och hals, u.å. HTM-REF-054

    Regionala cancercentrum i samverkan. Min vårdplan - huvud- och halscancer.

  53. Behroozian et al., 2023 HTM-REF-055

    Behroozian T, Goldshtein D, Ryan Wolf J, et al. MASCC clinical practice guidelines for the prevention and management of acute radiation dermatitis: part 2) recommendation formulation. Lancet Oncology. 2023;24(4):e172-e185.

  54. Robijns et al., 2018 HTM-REF-056

    Robijns J, Censabella S, Claes S, et al. Prevention of acute radiodermatitis by photobiomodulation: a randomized, placebo-controlled trial in breast cancer patients. Lasers in Surgery and Medicine. 2018;50(7):763-771.

  55. Robijns et al., 2022a HTM-REF-057

    Robijns J, Lodewijckx J, Bensadoun RJ, Mebis J. Photobiomodulation therapy for the prevention of acute radiation dermatitis in breast cancer patients undergoing hypofractionated whole-breast irradiation: the LABRA trial. Lasers in Surgery and Medicine. 2022;54. PubMed.

  56. Gobbo et al., 2023 HTM-REF-058

    Gobbo M, Ottaviani G, Perinetti G, et al. Photobiomodulation therapy for the prevention of acute radiation dermatitis: a systematic review and meta-analysis. Supportive Care in Cancer. 2023. PubMed.

  57. Lin et al., 2025 HTM-REF-059

    Lin YT, et al. Effects of photobiomodulation therapy for acute radiation dermatitis in patients with cancer: a systematic review and meta-analysis of real-world evidence. Radiotherapy and Oncology. 2025. PubMed.

  58. Robijns et al., 2022b HTM-REF-060

    Robijns J, Nair RG, Lodewijckx J, et al. Photobiomodulation therapy in management of cancer therapy-induced side effects: WALT position paper 2022. Frontiers in Oncology. 2022;12:927685.

  59. Baxter et al., 2017 HTM-REF-061

    Baxter GD, Liu L, Tumilty S, et al. Low level laser therapy for the management of breast cancer-related lymphedema: a systematic review. BMC Cancer. 2017;17:833.

  60. Wang et al., 2022 HTM-REF-062

    Wang Y, Ge Y, Xing W, et al. The effectiveness and safety of low-level laser therapy on breast cancer-related lymphedema: an overview and update of systematic reviews. Lasers in Medical Science. 2022;37:1389-1413.

  61. National Cancer Institute, 2025 HTM-REF-063

    National Cancer Institute. Photobiomodulation with light-emitting diode therapy for radiation fibrosis syndrome in patients with head and neck cancer. Clinical trial NCI-2025-01224.

  62. Louzeiro et al., 2020 HTM-REF-064

    Louzeiro GC, Cherubini K, de Figueiredo MAZ, Salum FG. Does laser photobiomodulation prevent hyposalivation in patients undergoing head and neck radiotherapy? A systematic review and meta-analysis of controlled trials. Critical Reviews in Oncology/Hematology. 2020;156:103115.

  63. Silva et al., 2021 HTM-REF-065

    Silva et al. LED-based photobiomodulation in the management of vaginal stenosis following pelvic radiotherapy: case report. 2021.

  64. RCC Huvud- och halscancer, 2026 HTM-REF-066

    Regionala cancercentrum i samverkan. Nationellt vårdprogram huvud- och halscancer. Version 3.2, 9 juni 2026. Avsnitt 15.5.2 och 15.5.6.

  65. Iovoli et al., 2023 HTM-REF-067

    Iovoli AJ, Turecki L, Qiu ML, et al. Severe Oral Mucositis After Intensity-Modulated Radiation Therapy for Head and Neck Cancer. JAMA Network Open. 2023;6(10).

  66. Käypä hoito, 2026 HTM-REF-068

    Suomalainen Lääkäriseura Duodecim och Suomen Hammaslääkäriseura Apollonia. Suusyöpä. Käypä hoito -suositus. Publicerad 26 maj 2026. Avsnittet Sädemukosiitti.

  67. de Lima et al., 2020 HTM-REF-069

    de Lima VHS, de Oliveira-Neto OB, da Hora Sales PH, et al. Effectiveness of low-level laser therapy for oral mucositis prevention in patients undergoing chemoradiotherapy for the treatment of head and neck cancer: a systematic review and meta-analysis. Oral Oncology. 2020;102:104524.

  68. Shen et al., 2024 HTM-REF-070

    Shen B, Zhou Y, Wu D, Liu J. Efficacy of photobiomodulation therapy in the management of oral mucositis in patients with head and neck cancer: a systematic review and meta-analysis of randomized controlled trials. Head & Neck. 2024;46(4):936-950.

  69. Kwok et al., 2026 HTM-REF-076

    Kwok ST, Lau LSK, Chan TO, et al. The efficacy of scalp cooling in patients receiving chemotherapy for primary gynecologic cancers: a randomized controlled trial. Sci Rep. 2026;16(1):14109.

  70. Kumar et al., 2025 HTM-REF-077

    Kumar PA, Sampat P, Sandhu M, et al. A meta-analysis of the utility of cryotherapy for preventing peripheral neuropathy among breast cancer patients receiving paclitaxel and nab-paclitaxel. Breast Cancer Res Treat. 2025;210:595-604.

  71. Oneda et al., 2021 HTM-REF-078

    Oneda E, Abeni C, Zanotti L, Zaina E, Bighè S, Zaniboni A. Chemotherapy-induced neurotoxicity in the treatment of gynecological cancers: state of art and an innovative approach for prevention. World J Clin Oncol. 2021;12(6):458-467.

  72. Bates och Knepil, 2016 HTM-REF-084

    Bates AS, Knepil GJ. Systematic review and meta-analysis of the efficacy of hilotherapy following oral and maxillofacial surgery. Int J Oral Maxillofac Surg. 2016;45(1):110–117.

  73. Glass et al., 2016 HTM-REF-085

    Glass GE, Waterhouse N, Shakib K. Hilotherapy for the management of perioperative pain and swelling in facial surgery: a systematic review and meta-analysis. Br J Oral Maxillofac Surg. 2016;54(8):851–856.

  74. Liu et al., 2025 HTM-REF-086

    Liu J, Fan W, Guo Y, Kopecky A, Wawer Matos Reimer PA, Heindl LM, et al. Eyelid edema reduction following blepharoplasty: a 3D imaging-based pilot study on the efficacy of Hilotherapy. Quant Imaging Med Surg. 2025;15(10):9170–9178.

  75. Jones et al., 2011 HTM-REF-087

    Jones BM, Grover R, Southwell-Keely JP. Post-operative hilotherapy in SMAS-based facelift surgery: a prospective, randomised, controlled trial. J Plast Reconstr Aesthet Surg. 2011;64(9):1132–1137.

  76. Liang et al., 2024 HTM-REF-088

    Liang Z, Ding Z, Wang D, Guo Y, Zhu L, Luo Z, et al. Cryotherapy for Rehabilitation After Total Knee Arthroplasty: A Comprehensive Systematic Review and Meta-Analysis. Orthop Surg. 2024;16(12):2897–2915.

  77. ONS, USA 2025 HTM-REF-089

    Oncology Nursing Society (ONS). Extremity Cryotherapy for Peripheral Neuropathy. ONS Symptom Management Resources. Evidence update, 1 April 2025.

  78. St. Gallen 2025 HTM-REF-090

    Burstein HJ, Curigliano G, Gnant M, Loibl S, Regan MM, Loi S, et al. Tailoring treatment to cancer risk and patient preference: The 2025 St Gallen International Breast Cancer Consensus Statement on individualizing therapy for patients with early breast cancer. Annals of Oncology. 2025;36(12):1433–1446.

  79. ESMO 2020 HTM-REF-091

    Jordan B, Margulies A, Cardoso F, Cavaletti G, Haugnes HS, Jahn P, et al. Systemic anticancer therapy-induced peripheral and central neurotoxicity: ESMO–EONS–EANO Clinical Practice Guidelines for diagnosis, prevention, treatment and follow-up. Annals of Oncology. 2020;31(10):1306–1319.

  80. eviQ 2026 HTM-REF-092

    Cancer Institute NSW, eviQ Cancer Treatments Online. Cryotherapy and compression to prevent taxane induced peripheral neuropathy. Clinical Resource ID 4618, version 1. Godkänd 27 november 2025, senast uppdaterad 26 juni 2026.